Immune checkpoint blocking therapies, or ICBs, help fight cancer by inhibiting the down-regulation of effector T cell activity. Here, two CD8+ T cells (in blue) approach a cancer cell (in brown), while ICB antibodies flow in from the upper right to block interaction between PD-1 and PDL-1. Peptide fragments (in red) are being presented by the cancer cell on its surface in HLA-I (Human Leukocyte Antigen) molecules, which make up
Illustration created during the Neuroanatomy course in the Medical and Biological Illustration graduate program at the Department of Art as Applied to Medicine, Johns Hopkins University School of Medicine. This illustration teaches the anatomy of the human brain around the lateral ventricle, a fluid-filled space that extends into the temporal lobe. The brain has been cut in several planes to expose the floor of the left lateral ventricle and the
Editorial illustration created during the Medical and Biological Illustration graduate program at Johns Hopkins University School of Medicine. The article chosen to be illustrated was: Willyard, C. 2018. Send in the germs: Lab mice are usually kept squeaky clean, but some immunologists think a dose of dirt could make them more useful for science. Nature, 556: 16-18.